Increasing evidences suggest that mitochondrial dysfunction plays an important role in the
pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) …

The dominant nature of the Huntington's disease gene mutation has allowed genetic models
to be developed in multiple species, with the mutation causing an abnormal neurological …

Nine novel β-and γ-carboline derivatives bearing either methyl-, propargyl-or phenethyl-
residues at the indole nitrogen were synthesized and tested as potential anti-Alzheimer …

Latrepirdine (Dimebon TM) was originally marketed as a non-selective antihistamine in
Russia. It was repurposed as an effective treatment for patients suffering from Alzheimer's …

Latrepirdine (Dimebon™), an anti-histamine, has shown some benefits in trials of
neurodegenerative diseases characterized by accumulation of aggregated or misfolded …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by beta-amyloid
plaques accumulation and cognitive impairment. Both environmental factors and heritable …

Although everyone would agree that successful translation of therapeutic candidates for
central nervous disorders should involve non-human primate (nhp) models of cognitive …

Neurodegenerative disorders, eg Parkinson's, Huntington's and Alzheimer's diseases are
distinct clinical and pathological entities sharing a number of leading features in their …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative diseases in the elderly. The key histopathological features of these …

Because of the failure of all amyloid-β directed treatment strategies for Alzheimer's disease
(AD), the concept of mitochondrial dysfunction as a major pathomechanism of the cognitive …