OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

SE Murthy, AE Dubin, T Whitwam, S Jojoa-Cruz… - Elife, 2018 - elifesciences.org
Mechanically activated (MA) ion channels convert physical forces into electrical signals, and
are essential for eukaryotic physiology. Despite their importance, few bona-fide MA …

Function investigations and applications of membrane proteins on artificial lipid membranes

T Tosaka, K Kamiya - International Journal of Molecular Sciences, 2023 - mdpi.com
Membrane proteins play an important role in key cellular functions, such as signal
transduction, apoptosis, and metabolism. Therefore, structural and functional studies of …

Ultrasonic control of neural activity through activation of the mechanosensitive channel MscL

J Ye, S Tang, L Meng, X Li, X Wen, S Chen, L Niu… - Nano …, 2018 - ACS Publications
Externally controlling the excitation of a neuronal subset through ion channels activation can
modulate the firing pattern of an entire neural circuit in vivo. As nanovalves in the cell …

Synthetic cell as a platform for understanding membrane-membrane interactions

B Sharma, H Moghimianavval, SW Hwang, AP Liu - Membranes, 2021 - mdpi.com
In the pursuit of understanding life, model membranes made of phospholipids were
envisaged decades ago as a platform for the bottom-up study of biological processes …

Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation

J Li, WD Jamieson, P Dimitriou, W Xu, P Rohde… - Nature …, 2022 - nature.com
Intracellular compartments are functional units that support the metabolism within living
cells, through spatiotemporal regulation of chemical reactions and biological processes …

Mechanosensitive channel-based optical membrane tension reporter

YY Hsu, AM Resto Irizarry, J Fu, AP Liu - ACS sensors, 2023 - ACS Publications
Plasma membrane tension functions as a global physical organizer of cellular activities.
Technical limitations of current membrane tension measurement techniques have hampered …

Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels

CD Cox, Y Zhang, Z Zhou, T Walz… - Proceedings of the …, 2021 - National Acad Sciences
The bacterial mechanosensitive channel of small conductance (MscS) has been extensively
studied to understand how mechanical forces are converted into the conformational …

Corynebacterium glutamicum mechanosensitive channels: towards unpuzzling “glutamate efflux” for amino acid production

Y Nakayama, K Hashimoto, Y Sawada, M Sokabe… - Biophysical …, 2018 - Springer
Corynebacterium glutamicum has been utilized for industrial amino acid production,
especially for monosodium glutamate (MSG), the food-additive for the “UMAMI” category of …

Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry

R Strutt, JW Hindley, J Gregg, PJ Booth, JD Harling… - Chemical …, 2021 - pubs.rsc.org
Droplet microcompartments linked by lipid bilayers show great promise in the construction of
synthetic minimal tissues. Central to controlling the flow of information in these systems are …

Droplet Polymer Bilayers for Bioelectronic Membrane Interfacing

EA Schafer, JJ Maraj, C Kenney… - Journal of the …, 2024 - ACS Publications
Model membranes interfaced with bioelectronics allow for the exploration of fundamental
cell processes and the design of biomimetic sensors. Organic conducting polymers are an …