Growth factors in the carotid body—an update
The carotid body may undergo plasticity changes during development/ageing and in
response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli …
response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli …
Effects of the antipsychotic quetiapine on sleep and breathing: a review of clinical findings and potential mechanisms
Quetiapine is an antipsychotic medication indicated for schizophrenia and bipolar disorder.
However, quetiapine also has hypnotic properties and as such is increasingly being …
However, quetiapine also has hypnotic properties and as such is increasingly being …
Lactate sensing by neuroepithelial cells isolated from the gills of killifish (Fundulus heteroclitus)
EM Leonard, FE Weaver… - Journal of Experimental …, 2022 - journals.biologists.com
Lactate is produced in most vertebrate cells as a by-product of anaerobic metabolism. In
addition to its role as a fuel for many tissues, circulating lactate can act as a signalling …
addition to its role as a fuel for many tissues, circulating lactate can act as a signalling …
Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway
Y Huang, H Huang, L Zhou, J Li, X Chen… - Human molecular …, 2022 - academic.oup.com
The D620N mutation in vacuolar protein sorting protein 35 (VPS35) gene has been
identified to be linked to late onset familial Parkinson disease (PD). However, the …
identified to be linked to late onset familial Parkinson disease (PD). However, the …
Carotid body plastic behavior: evidence for D2–H3 receptor–receptor interactions
Dopamine and histamine receptors D2R and H3R are G protein-coupled receptors (GPCRs)
which can establish physical receptor–receptor interactions (RRIs), leading to homo/hetero …
which can establish physical receptor–receptor interactions (RRIs), leading to homo/hetero …
Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats
KV Pereyra, KG Schwarz… - American Journal …, 2021 - journals.physiology.org
Paraquat (PQT) herbicide is widely used in agricultural practices despite being highly toxic
to humans. It has been proposed that PQT exposure may promote cardiorespiratory …
to humans. It has been proposed that PQT exposure may promote cardiorespiratory …
Experimental Evidence of A2A–D2 Receptor–Receptor Interactions in the Rat and Human Carotid Body
Adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) are known to be
involved in the physiological response to hypoxia, and their expression/activity may be …
involved in the physiological response to hypoxia, and their expression/activity may be …
Lactate does not activate the carotid body of Wistar rat
The carotid body's glomus cells are the primary sensors of hypoxia in mammals. Previous
studies suggested that the glomus cells' hypoxia sensitivity is mediated by lactate in mice …
studies suggested that the glomus cells' hypoxia sensitivity is mediated by lactate in mice …
The association between notching of the right ventricular outflow tract flow velocity doppler envelope and impaired right ventricular function after acute high-altitude …
F Yuan, C Liu, S Yu, S Bian, J Yang, X Ding… - Frontiers in …, 2021 - frontiersin.org
Introduction Pulmonary artery pressure (PAP) is increased and right ventricular (RV) function
is well preserved in healthy subjects upon exposure to high altitude (HA). An increase in …
is well preserved in healthy subjects upon exposure to high altitude (HA). An increase in …
The Carotid Body “Tripartite Synapse”: Role of Gliotransmission
EM Leonard, CA Nurse - International Society for Arterial Chemoreception, 2022 - Springer
In mammals, cardiorespiratory reflexes originating in the carotid body (CB) help maintain
homeostasis by matching oxygen supply to oxygen demand. CB output to the brainstem is …
homeostasis by matching oxygen supply to oxygen demand. CB output to the brainstem is …