The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively
in recent decades and a large body of information is now available to the scientific …

Cell-mediated immunity (T cells) and nonspecific cellular immunity (ie, macrophage, NK
cells, and neutrophils) are generally believed to provide the main defenses against fungi …

Only two decades ago antibodies to fungi were thought to have little or no role in protection
against fungal diseases. However, subsequent research has provided convincing evidence …

Glycoconjugate vaccines, in which a cell surface carbohydrate from a micro-organism is
covalently attached to an appropriate carrier protein are proving to be the most effective …

The latter part of the 20th century has witnessed an unprecedented rise in the number of
individuals with impaired immunity. This is primarily attributable to the increased …

Brain infection by the fungus Cryptococcus neoformans results in inflammation of the
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …

Among viral, bacterial, and fungal diseases, the latter are the only branch of infectious
diseases without a vaccine for any of their causative agents. This is at odds with a disease …

Abstract Defined Abs to the Cryptococcus neoformans capsular polysaccharide
glucuronoxylomannan (GXM) have been shown to be protective against experimental …

Antibodies reactive with the cryptococcal polysaccharide glucuronoxylomannan (GXM) are
present in sera from both human immunodeficiency virus (HIV)—uninfected and—infected …

Abstract The IgM mAbs 12A1 and 13F1 are protective and nonprotective, respectively,
against lethal Cryptococcus neoformans infection in mice. To better understand the …