Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).

A Sancar - Angewandte Chemie International Edition, 2016 - search.ebscohost.com
The article presents the result of a study which examined DNA repair through photolyase in
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …

Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

AQ Khan, JB Travers, MG Kemp - Environmental and molecular …, 2018 - Wiley Online Library
The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

NL Yuwono, K Warton, CE Ford - Elife, 2021 - elifesciences.org
Research and clinical use of circulating cell-free DNA (cirDNA) is expanding rapidly;
however, there remain large gaps in our understanding of the influence of lifestyle and …

Neuropsin (OPN5) mediates local light-dependent induction of circadian clock genes and circadian photoentrainment in exposed murine skin

ED Buhr, S Vemaraju, N Diaz, RA Lang… - Current Biology, 2019 - cell.com
Nearly all mammalian tissues have functional, autonomous circadian clocks, which free-run
with non-24 h periods and must be synchronized (entrained) to the 24 h day. This …

The circadian clock and metabolic homeostasis: entangled networks

LVM de Assis, H Oster - Cellular and Molecular Life Sciences, 2021 - Springer
The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

The circadian clock and diseases of the skin

J Duan, EN Greenberg, SS Karri, B Andersen - FEBS letters, 2021 - Wiley Online Library
Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and
adapt to daily changes in the environment. Synchronized to the light–dark cycle with a …

Biological rhythms in the skin

MS Matsui, E Pelle, K Dong, N Pernodet - International journal of …, 2016 - mdpi.com
Circadian rhythms,≈ 24 h oscillations in behavior and physiology, are reflected in all cells of
the body and function to optimize cellular functions and meet environmental challenges …

Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma

LVCM De Assis, GS Kinker, MN Moraes… - Frontiers in …, 2018 - frontiersin.org
Introduction Melanoma is the most lethal type of skin cancer, with increasing incidence and
mortality rates worldwide. Multiple studies have demonstrated a link between cancer …

The impact of the circadian clock on skin physiology and cancer development

JE Lubov, W Cvammen, MG Kemp - International Journal of Molecular …, 2021 - mdpi.com
Skin cancers are growing in incidence worldwide and are primarily caused by exposures to
ultraviolet (UV) wavelengths of sunlight. UV radiation induces the formation of photoproducts …

Novel approaches for managing aged skin and nonmelanoma skin cancer

K Todorova, A Mandinova - Advanced Drug Delivery Reviews, 2020 - Elsevier
The process of aging influences every bodily organ and tissue, and those with rapid
epithelial cell turnover, are particularly affected. The most visible of these, however, is the …