Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents

J Holenz, PJ Pauwels, JL Díaz, R Mercè, X Codony… - Drug Discovery …, 2006 - Elsevier
Although the 5-hydroxytryptamine6 (5-HT6) receptor was discovered only recently, its almost
exclusive distribution in the brain makes it a promising, novel, target for central nervous …

The biological and pharmacological potentials of indole-based heterocycles

S Sharma, S Singh - Letters in Organic Chemistry, 2023 - benthamdirect.com
An important bioactive heterocycle having several uses in medicinal chemistry, synthetic
organic chemistry, material chemistry, and natural product is indole along with its analogues …

Enantioselective Friedel− Crafts alkylations of α, β-unsaturated 2-acyl imidazoles catalyzed by bis (oxazolinyl) pyridine− scandium (III) triflate complexes

DA Evans, KR Fandrick, HJ Song - Journal of the American …, 2005 - ACS Publications
An enantioselective Friedel− Crafts alkylation with α, β-unsaturated 2-acyl imidazoles and
electron-rich aromatic nucleophiles catalyzed by bis (oxazolinyl) pyridine− scandium (III) …

Enantioselective Friedel− Crafts alkylations catalyzed by bis (oxazolinyl) pyridine− Scandium (III) triflate complexes

DA Evans, KR Fandrick, HJ Song… - Journal of the …, 2007 - ACS Publications
The enantioselective Friedel− Crafts addition of a variety of indoles catalyzed by bis
(oxazolinyl) pyridine− scandium (III) triflate complexes (Sc (III)− pybox) was accomplished …

Highly enantioselective Friedel− Crafts alkylations of indoles with simple enones catalyzed by Zirconium (IV)− BINOL complexes

G Blay, I Fernández, JR Pedro, C Vila - Organic Letters, 2007 - ACS Publications
Complexes of BINOL-based ligands with Zr (O t Bu) 4 catalyze the Friedel− Crafts alkylation
reaction of indoles and pyrrole with nonchelating β-substituted α, β-enones at room …

Mild Cobalt (III)‐Catalyzed C–H Hydroarylation of Conjugated C= C/C= O Bonds

J Li, Z Zhang, W Ma, M Tang, D Wang… - Advanced Synthesis & …, 2017 - Wiley Online Library
An efficient cobalt (III)‐catalyzed C‐2‐selective indole C–H hydroarylation of acrolein,
enones, and glyoxylates was achieved under mild reaction conditions. The versatile cobalt …

A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine6 (5-HT6) Receptor Antagonists

ML López-Rodríguez, B Benhamú… - Journal of medicinal …, 2005 - ACS Publications
Forty-five structurally diverse 5-hydroxytryptamine6 receptor (5-HT6R) antagonists were
selected to develop a 3D pharmacophore model with the Catalyst software. The structural …

5-HT6 receptor antagonists as potential therapeutics for cognitive impairment

G Rosse, H Schaffhauser - Current topics in medicinal …, 2010 - ingentaconnect.com
Cognitive impairment (CI) has been recognized as a core feature of Alzheimer's disease
(AD) and schizophrenia. The 5-HT6 receptor is an attractive target for the development of …

[PDF][PDF] Enantioselective Synthesis of Tetrahydrocarbazoles through a Michael Addition/Ciamician–Plancher Rearrangement Sequence: Asymmetric Synthesis of a …

CCJ Loh, G Raabe, D Enders - Chemistry-a European Journal, 2012 - academia.edu
Indole and its derivatives are at the moment one of the most intensively investigated
classical heterocycles because of their prevalence in bioactive compounds and their …

Amine‐Terminated Ionic Liquid Modified Magnetic Graphene Oxide (MGO‐IL‐NH2): A Highly Efficient and Reusable Nanocatalyst for the Synthesis of 3‐Amino …

C Garkoti, J Shabir, S Mozumdar - ChemistrySelect, 2020 - Wiley Online Library
Amine‐terminated ionic liquid has been covalently fabricated over the surface of Magnetic
graphene oxide nanosheets. The structure of prepared material has been confirmed by …