[HTML][HTML] CD4+ T cell memory
M Künzli, D Masopust - Nature immunology, 2023 - nature.com
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …
peptide complexes to control phagosomal infections, help B cells, regulate tissue …
Glomerulonephritis: immunopathogenesis and immunotherapy
Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …
Clonal expansion and activation of tissue-resident memory-like TH17 cells expressing GM-CSF in the lungs of patients with severe COVID-19
Hyperinflammation contributes to lung injury and subsequent acute respiratory distress
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …
syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19) …
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening
autoimmune disease that often results in kidney failure caused by crescentic …
autoimmune disease that often results in kidney failure caused by crescentic …
Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Our understanding of tissue-resident memory T (TRM) cell biology has been largely
developed from acute infection models in which antigen is cleared and sterilizing immunity …
developed from acute infection models in which antigen is cleared and sterilizing immunity …
Tissue-resident memory T cells in tumor immunity and immunotherapy
Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the
functionality of both effector and memory T cells. TRM express residence gene signatures …
functionality of both effector and memory T cells. TRM express residence gene signatures …
Th17 cells and inflammation in neurological disorders: Possible mechanisms of action
Y Shi, B Wei, L Li, B Wang, M Sun - Frontiers in immunology, 2022 - frontiersin.org
Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …
neuroinflammatory response has been reported to be associated with the pathogenesis of …
Cytokine‐regulated Th17 plasticity in human health and diseases
Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …
lineages depending on the local cytokine environment. However, these polarized Th cells …
The m6A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
Excessive cytokine activity underlies many autoimmune conditions, particularly through the
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
ATH17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
Steroid resistance poses a major challenge for the management of autoimmune
neuroinflammation. T helper 17 (TH17) cells are widely implicated in the pathology of steroid …
neuroinflammation. T helper 17 (TH17) cells are widely implicated in the pathology of steroid …