Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an
epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely …

The reversible acetylation of histone lysine residues is controlled by the action of
acetyltransferases and deacetylases (HDACs), which regulate chromatin structure and gene …

The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for
mammalian embryogenesis and is implicated in human congenital diseases and multiple …

As a flavin adenine dinucleotide (FAD)-dependent monoamine oxidase, lysine specific
demethylase 1 (LSD1/KDM1A) functions as a transcription coactivator or corepressor to …

Biochemical crosstalk between two or more histone modifications is often observed in
epigenetic enzyme regulation, but its functional significance in cells has been difficult to …

Lysine-specific histone demethylase 1 (LSD1), which demethylates mono-or di-methylated
histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …

Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer
(OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in …