The human genetic code encrypted in thousands of genes holds the secret for synthesis of
proteins that drive all biological processes necessary for normal life and death. Though the …

Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

In 1996, in a discussion of adenovirus biology in a standard virology textbook, it was noted
that “the identity of the cellular receptor remains a mystery”(78). In the past few years, not just …

Adenoviruses (Ad) are efficient vehicles for gene delivery in vitro and in vivo. Therefore, they
are a promising tool in gene therapy, particularly in the treatment of cancer and …

Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in
clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a …

Rational development of adenovirus vectors for therapeutic gene transfer is hampered by
the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom …

Oncolytic virotherapy is a promising alternative to conventional treatment, yet systemic
delivery of these viruses to tumors remains a major challenge. In this regard, mesenchymal …

After intravenous administration, adenovirus (Ad) vectors are predominantly sequestered by
the liver. Delineating the mechanisms for Ad accumulation in the liver is crucial for a better …

Adenovirus is a robust vector for therapeutic applications, but its use is limited by our
understanding of its complex in vivo pharmacology. In this review we describe the necessity …

Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the
treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad …