All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders

G Northoff, D Hirjak, RC Wolf, P Magioncalda… - Molecular …, 2021 - nature.com
Psychomotor abnormalities have been abundantly observed in psychiatric disorders like
major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCH). Although …

[HTML][HTML] Primary motor cortex in Parkinson's disease: Functional changes and opportunities for neurostimulation

CF Underwood, LC Parr-Brownlie - Neurobiology of Disease, 2021 - Elsevier
Movement abnormalities of Parkinson's disease (PD) arise from disordered neural activity in
multiple interconnected brain structures. The planning and execution of movement requires …

[HTML][HTML] Short-term plasticity of the motor cortex compensates for bradykinesia in Parkinson's disease

A Guerra, D Colella, A Cannavacciuolo… - Neurobiology of …, 2023 - Elsevier
Patients with Parkinson's disease (PD) show impaired short-term potentiation (STP)
mechanisms in the primary motor cortex (M1). However, the role played by this …

[HTML][HTML] Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation

KAM Pauls, O Korsun, J Nenonen, J Nurminen… - NeuroImage, 2022 - Elsevier
Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …

GABAergic changes in the thalamocortical circuit in Parkinson's disease

AJM van Nuland, HEM den Ouden, H Zach… - Human Brain …, 2020 - Wiley Online Library
Parkinson's disease is characterized by bradykinesia, rigidity, and tremor. These symptoms
have been related to an increased gamma‐aminobutyric acid (GABA) ergic inhibitory drive …

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

LI Boon, VJ Geraedts, A Hillebrand… - Human brain …, 2019 - Wiley Online Library
Parkinson's disease (PD) is accompanied by functional changes throughout the brain,
including changes in the electromagnetic activity recorded with magnetoencephalography …

Dysfunction of motor cortices in Parkinson's disease

HY Chu, Y Smith, WW Lytton, S Grafton… - Cerebral …, 2024 - academic.oup.com
The cerebral cortex has long been thought to be involved in the pathophysiology of motor
symptoms of Parkinson's disease. The impaired cortical function is believed to be a direct …

Modulation of post‐movement beta rebound by contraction force and rate of force development

A Fry, KJ Mullinger, GC O'Neill, EL Barratt… - Human brain …, 2016 - Wiley Online Library
Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory
phenomena in the brain. In the preparation and execution phases of movement, a loss in …

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

L Chi, B Gao, X Bian, P Tu, H Ru, K Lu - Toxicology and applied …, 2017 - Elsevier
Overexposure to manganese (Mn) leads to toxic effects, such as promoting the development
of Parkinson's-like neurological disorders. The gut microbiome is deeply involved in immune …

[HTML][HTML] The cortical signature of symptom laterality in Parkinson's disease

E Heinrichs-Graham, PM Santamaria… - NeuroImage: Clinical, 2017 - Elsevier
Patients with Parkinson's disease (PD) often present with unilateral motor symptoms that
eventually spread to the other side. This symptom lateralization is diagnostically important …