Building a model of the brain: from detailed connectivity maps to network organization

RO Shimoura, RFO Pena, V Lima, NL Kamiji… - The European Physical …, 2021 - Springer
The field of computational modeling of the brain is advancing so rapidly that now it is
possible to model large scale networks representing different brain regions with a high level …

Towards a large-scale biologically realistic model of the hippocampus

PJ Hendrickson, JY Gene, BS Robinson… - … Conference of the …, 2012 - ieeexplore.ieee.org
Real neurobiological systems in the mammalian brain have a complicated and detailed
structure, being composed of 1) large numbers of neurons with intricate, branching …

A million-plus neuron model of the hippocampal dentate gyrus: Dependency of spatio-temporal network dynamics on topography

PJ Hendrickson, JY Gene, D Song… - 2015 37th Annual …, 2015 - ieeexplore.ieee.org
This paper describes a million-plus granule cell compartmental model of the rat
hippocampal dentate gyrus, including excitatory, perforant path input from the entorhinal …

Implementation of activity-dependent synaptic plasticity rules for a large-scale biologically realistic model of the hippocampus

BS Robinson, JY Gene, PJ Hendrickson… - … Conference of the …, 2012 - ieeexplore.ieee.org
A large-scale computational model of the hippocampus should consider plasticity at different
time scales in order to capture the non-stationary information processing behavior of the …

Implementation of the excitatory entorhinal-dentate-CA3 topography in a large-scale computational model of the rat hippocampus

G Yu, D Song, TW Berger - 2014 36th Annual International …, 2014 - ieeexplore.ieee.org
The topography, or the anatomical connectivity, of the excitatory entorhinal-dentate-CA3
circuit of the rat hippocampus has been implemented for a large-scale, biologically realistic …

Topography-dependent spatio-temporal correlations in the entorhinal-dentate-CA3 circuit in a large-scale computational model of the Rat Hippocampus

JY Gene, PJ Hendrickson, D Song… - 2015 37th Annual …, 2015 - ieeexplore.ieee.org
The correlation due to different topographies was characterized in a large-scale, biologically-
realistic, computational model of the rat hippocampus using a spatio-temporal correlation …

A 3-D admittance-level computational model of a rat hippocampus for improving prosthetic design

A Gilbert, K Loizos, AK RamRakhyani… - 2015 37th Annual …, 2015 - ieeexplore.ieee.org
Hippocampal prosthetic devices have been developed to bridge the gap between
functioning portions of the hippocampus, in order to restore lost memory functionality in …

Modeling analysis of negative effects of high frequency electrical stimulation on axonal behaviors

L Sun, H Liu - 2013 35th Annual International Conference of …, 2013 - ieeexplore.ieee.org
High frequency biphasic (HFB) electrical stimulation were commonly used in nerve block.
This study constructed a double layer amphibian axonal model to explore the negative …

The role of topography in the transformation of spatiotemporal patterns by a large-scale, biologically realistic model of the rat dentate gyrus

JY Gene, PJ Hendrickson, BS Robinson… - 2013 35th Annual …, 2013 - ieeexplore.ieee.org
A large-scale, biologically realistic, computational model of the rat hippocampus is being
constructed to study the input-output transformation that the hippocampus performs. In the …

The contribution of relative activation levels between populations of cells to network activity in a large-scale biologically realistic model of the hippocampus

PJ Hendrickson, JY Gene, BS Robinson… - 2013 35th Annual …, 2013 - ieeexplore.ieee.org
In previously published work, we showed the progress we've made towards creating a large-
scale, biologically realistic model of the rat hippocampus, starting with the projection from …