Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

The process of senescence (aging) is predominantly determined by the action of wild-type
genes. For most organisms, this does not reflect any adaptive function that senescence …

The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the
insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS …

In post-reproductive C. elegans, destructive somatic biomass repurposing supports
production of yolk which, it was recently shown, is vented and can serve as a foodstuff for …

Maximum lifespan differs greatly between species, indicating that the process of senescence
is largely genetically determined. Senescence evolves in part due to antagonistic pleiotropy …

A key hypothesis for the occurrence of senescence is the decrease in selection strength due
to the decrease in the proportion of newborns from parents attaining an advanced age–the …

The aging process in semelparous and iteroparous species is different, but how different?
Death in semelparous organisms (eg, Pacific salmon) results from suicidal reproductive …

The age-related loss of protein homeostasis (proteostasis) is at the heart of numerous
neurodegenerative diseases. Therefore, finding ways to preserve proteome integrity in aged …

The last decade has seen remarkable progress in the characterization of methylation clocks
that can serve as indicators of biological age in humans and many other mammalian …

Classical evolutionary theories propose tradeoffs among reproduction, damage repair and
lifespan. However, the specific role of the germline in shaping vertebrate aging remains …