The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner
nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 …

The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects,
regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its …

The viscoelastic parameters of the cell can report on the cell state, cellular processes and
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …

SYNE1, a nuclear envelope protein critical for cellular structure and signaling, is
downregulated in numerous malignancies. SYNE1 alterations are found in 10% of …

In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …

Three major proteins in the nucleoskeleton, lamins, actin, and spectrin, play essential roles
in maintenance of nuclear architecture and the integrity of the nuclear envelope, in …

The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and
survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the …

This review presents a comprehensive exploration of the pivotal role played by the Linker of
Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin …

A number of studies have reported on the unusual pharmacological behavior of type I
antiestrogens, such as tamoxifen. These agents display mixed agonist/antagonist activity in …

The spectrin is first identified as the main component of erythrocyte membrane skeleton. It is
getting growing attention since being found in multiple nonerythroid cells, providing complex …