Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …

Liquid–liquid phase separation (LLPS) is an important mechanism enabling the dynamic
compartmentalization of macromolecules, including complex polymers such as proteins and …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

High-resolution structures of amyloid fibrils formed from normally-folded proteins have
revealed non-native conformations of the polypeptide chains. Attaining these conformations …

Protein phase separation is increasingly understood to be an important mechanism of
biological organization and biomaterial formation. Intrinsically disordered protein regions …

The nuclear envelope (NE) is a bilayer membrane that separates and physically isolates the
genetic material from the cytoplasm. Nuclear pore complexes (NPCs) are cylindrical …