The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Oxygen is necessary for life yet too much or too little oxygen is toxic to cells. The oxygen
tension in the maternal plasma bathing placental villi is< 20mmHg until 10–12 weeks' …

Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part
through disrupted placental functions, which may be reflected in the placental epigenome …

Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However,
the exact mechanisms underlying this process are not well understood. Moreover, according …

Autophagy is a highly regulated and dynamic process that maintains cellular homeostasis
and plays a prosurvival role in most cells. Although hypoxia has been shown to induce …

Placental dysfunction is the underlying cause of pregnancy complications such as fetal
growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly …

The epidermal growth factor receptor (EGFR) is expressed robustly in the placenta, and
critical processes of pregnancy such as placental growth and trophoblast fusion are …

Objective Maternal cigarette smoking is reportedly associated with miscarriage, fetal growth
restriction and placental abruption, and is paradoxically associated with a decreased risk of …

Hypoxia is commonly assigned a role in the placental dysfunction characteristic of
preeclampsia and intrauterine growth restriction. We previously showed that hypoxia …