Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

The bioconjugation of proteins—that is, the creation of a covalent link between a protein and
any other molecule—has been studied for decades, partly because of the numerous …

Protein conjugates are valuable tools for studying biological processes or producing
therapeutics, such as antibody–drug conjugates. Despite the development of several protein …

Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

Recently, reversible click reactions have found numerous applications in chemical biology,
supramolecular chemistry, and biomedical applications. Boronic acid (BA)-mediated cis-diol …

Numerous strategies for linking desired chemical probes with target peptides and proteins
have been developed and applied in the field of biological chemistry. Approaches for site …

The demand for creation of protein diversity and regulation of protein function through native
protein modification and post-translational modification has ignited the development of …

Advances in the site-specific chemical modification of proteins, also referred to as protein
bioconjugation, have proved instrumental in revolutionary approaches to designing new …

Cyclization provides a general strategy for improving the proteolytic stability, cell membrane
permeability and target binding affinity of peptides. Insertion of a stable, non-reducible linker …

Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies,
peptides and other targeting units. However, one main drawback is the occurrence of thiol …