Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

▪ Abstract Proteases from a variety of protozoan parasites have been characterized at the
molecular and cellular levels, and the many roles that proteases play in these organisms are …

The parasitic protozoan Trypanosoma cruzi employs multiple molecular strategies to invade
a broad range of nonphagocytic cells. Here we demonstrate that the invasion of human …

This chapter discusses the clinical features, pathology, infection process and pathogenesis
of, as well as immune responses to, trypanosomiasis in domestic animals. The host and …

It has been shown that lysosomal cysteine proteinases, specially cathepsin B, has been
implicated in a variety of diseases involving tissue remodeling states, such as inflammation …

Mammalian cell invasion by the protozoan pathogen Trypanosoma cruzi is critical to its
survival in the host. To promote its entry into a wide variety of non‐professional phagocytic …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains
cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among …

Trypanosomes and Leishmania contain an abundance of stage-regulated cysteine
proteinases encoded by several gene families. Analysis of parasites rendered defective in …

Cruzain is the major papain-like cysteine protease of Trypanosoma cruzi, the etiological
agent causing Chagas' disease in humans in South America. Cruzain is indispensable for …