[PDF][PDF] Excess weight gain with integrase inhibitors and tenofovir alafenamide: what is the mechanism and does it matter?

BR Wood, GD Huhn - Open forum infectious diseases, 2021 - academic.oup.com
Numerous studies have detected a greater likelihood of excess weight gain with specific
antiretrovirals (ARVs), particularly tenofovir alafenamide and integrase inhibitors, as …

Osteoporosis and HIV infection

E Biver - Calcified Tissue International, 2022 - Springer
Life expectancy of people living with HIV (PLWH) is now close to that of the HIV-uninfected
population. As a result, age-related comorbidities, including osteoporosis, are increasing in …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society–USA panel

RT Gandhi, R Bedimo, JF Hoy, RJ Landovitz, DM Smith… - Jama, 2023 - jamanetwork.com
Importance Recent advances in treatment and prevention of HIV warrant updated
recommendations to guide optimal practice. Objective Based on a critical evaluation of new …

Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)

J Bischoff, W Gu, C Schwarze-Zander… - …, 2021 - thelancet.com
Background De novo steatosis is the main criteria for non-alcoholic fatty liver disease
(NAFLD), which is becoming a clinically relevant comorbidity in HIV-infected patients. This …

Contemporary antiretrovirals and body-mass index: a prospective study of the RESPOND cohort consortium

L Bansi-Matharu, A Phillips, C Oprea… - The Lancet …, 2021 - thelancet.com
Background Weight gain effects of individual antiretroviral drugs are not fully understood.
We investigated associations between a prespecified clinically significant increase (> 7%) in …

Weight gain after HIV therapy initiation: pathophysiology and implications

NC Chandiwana, MJ Siedner… - The Journal of …, 2024 - academic.oup.com
Rapid advances in the potency, safety, and availability of modern HIV antiretroviral therapy
(ART) have yielded a near-normal life expectancy for most people living with HIV (PLWH) …

[PDF][PDF] BHIVA guidelines on antiretroviral treatment for adults living with HIV-1 2022

L Waters, A Winston, I Reeves, M Boffito… - HIV …, 2022 - discovery.ucl.ac.uk
The overall purpose of these guidelines is to provide guidance on best clinical practice for
antiretroviral therapy (ART) and management of adults living with human immunodeficiency …

Is tenofovir disoproxil fumarate associated with weight loss?

S Shah, V Pilkington, A Hill - Aids, 2021 - journals.lww.com
Background: Recent clinical trials have shown weight gain associated with newer
antiretrovirals. It is unclear how the nucleoside reverse transcriptase inhibitor backbone …

Relationship between weight gain and insulin resistance in people living with HIV switching to integrase strand transfer inhibitors-based regimens

J Milic, S Renzetti, D Ferrari, S Barbieri, M Menozzi… - Aids, 2022 - journals.lww.com
Objective: The primary objective was to explore weight and BMI changes in people with HIV
(PWH) undergoing integrase strand transfer inhibitors (INSTI)-based regimens (vs. non …

Weight gain and metabolic effects in persons with HIV who switch to ART regimens containing integrase inhibitors or tenofovir alafenamide

FJ Palella, Q Hou, J Li, J Mahnken… - JAIDS Journal of …, 2023 - journals.lww.com
Background: The timing and magnitude of antiretroviral therapy–associated weight change
attributions are unclear. Setting: HIV Outpatient Study participants. Methods: We analyzed …