Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Climate change and global health: a call to more research and more action

I Agache, V Sampath, J Aguilera, CA Akdis, M Akdis… - Allergy, 2022 - Wiley Online Library
There is increasing understanding, globally, that climate change and increased pollution will
have a profound and mostly harmful effect on human health. This review brings together …

Allergy: Mechanistic insights into new methods of prevention and therapy

CA Akdis, M Akdis, SD Boyd, V Sampath… - Science Translational …, 2023 - science.org
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

Climate change and allergies

D Luschkova, C Traidl-Hoffmann, A Ludwig - Allergo Journal International, 2022 - Springer
The climate crisis poses a major challenge to human health as well as the healthcare
system and threatens to jeopardize the medical progress made in recent decades. However …

Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma

V Sampath, J Aguilera, M Prunicki, KC Nadeau - Seminars in immunology, 2023 - Elsevier
Climate change is considered the greatest threat to global health. Greenhouse gases as
well as global surface temperatures have increased causing more frequent and intense heat …

Increased duration of pollen and mold exposure are linked to climate change

B Paudel, T Chu, M Chen, V Sampath, M Prunicki… - Scientific reports, 2021 - nature.com
Pollen and molds are environmental allergens that are affected by climate change. As pollen
and molds exhibit geographical variations, we sought to understand the impact of climate …

[HTML][HTML] The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

D Yazici, I Ogulur, Y Pat, H Babayev, E Barletta… - Seminars in …, 2023 - Elsevier
Since the 1960 s, our health has been compromised by exposure to over 350,000 newly
introduced toxic substances, contributing to the current pandemic in allergic, autoimmune …

Effect of altered human exposome on the skin and mucosal epithelial barrier integrity

Y Pat, I Ogulur, D Yazici, Y Mitamura, L Cevhertas… - Tissue …, 2023 - Taylor & Francis
Pollution in the world and exposure of humans and nature to toxic substances is
continuously worsening at a rapid pace. In the last 60 years, human and domestic animal …

Climate change, airborne allergens, and three translational mitigation approaches

PJ Beggs, B Clot, M Sofiev, FH Johnston - EBioMedicine, 2023 - thelancet.com
One of the important adverse impacts of climate change on human health is increases in
allergic respiratory diseases such as allergic rhinitis and asthma. This impact is via the …

Acute and chronic impacts of heat stress on planetary health

V Sampath, O Shalakhti, E Veidis, JAI Efobi… - Allergy, 2023 - Wiley Online Library
Heat waves are increasing in intensity, frequency, and duration causing significant heat
stress in all living organisms. Heat stress has multiple negative effects on plants affecting …