Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Structural characterization of proteins and complexes using small-angle X-ray solution scattering

HDT Mertens, DI Svergun - Journal of structural biology, 2010 - Elsevier
Small-angle scattering of X-rays (SAXS) is an established method for the low-resolution
structural characterization of biological macromolecules in solution. The technique provides …

Spatiotemporal control of gene expression by a light-switchable transgene system

X Wang, X Chen, Y Yang - Nature methods, 2012 - nature.com
We developed a light-switchable transgene system based on a synthetic, genetically
encoded light-switchable transactivator. The transactivator binds promoters upon blue-light …

Nucleation and Growth of Gold Nanoparticles Studied via in situ Small Angle X-ray Scattering at Millisecond Time Resolution

J Polte, R Erler, AF Thunemann, S Sokolov, TT Ahner… - ACS …, 2010 - ACS Publications
Gold nanoparticles (AuNP) were prepared by the homogeneous mixing of continuous flows
of an aqueous tetrachloroauric acid solution and a sodium borohydride solution applying a …

LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling

A Pudasaini, KK El-Arab, BD Zoltowski - Frontiers in molecular …, 2015 - frontiersin.org
The Light-Oxygen-Voltage domain family of proteins is widespread in biology where they
impart sensory responses to signal transduction domains. The small, light responsive LOV …

At light speed: advances in optogenetic systems for regulating cell signaling and behavior

NA Repina, A Rosenbloom, A Mukherjee… - Annual review of …, 2017 - annualreviews.org
Cells are bombarded by extrinsic signals that dynamically change in time and space. Such
dynamic variations can exert profound effects on behaviors, including cellular signaling …

Photoreceptor engineering

T Ziegler, A Möglich - Frontiers in molecular biosciences, 2015 - frontiersin.org
Sensory photoreceptors not only control diverse adaptive responses in Nature, but as light-
regulated actuators they also provide the foundation for optogenetics, the non-invasive and …

t-Distributed stochastic neighbor embedding method with the least information loss for macromolecular simulations

H Zhou, F Wang, P Tao - Journal of chemical theory and …, 2018 - ACS Publications
Dimensionality reduction methods are usually applied on molecular dynamics simulations of
macromolecules for analysis and visualization purposes. It is normally desired that suitable …

Tripping the light fantastic: blue-light photoreceptors as examples of environmentally modulated protein− protein interactions

BD Zoltowski, KH Gardner - Biochemistry, 2011 - ACS Publications
Blue-light photoreceptors play a pivotal role in detecting the quality and quantity of light in
the environment, controlling a wide range of biological responses. Several families of blue …

Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora

CH Chen, BS DeMay, AS Gladfelter… - Proceedings of the …, 2010 - National Acad Sciences
Photoadaptation, the ability to attenuate a light response on prolonged light exposure while
remaining sensitive to escalating changes in light intensity, is essential for organisms to …