The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …