Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control

ME Youssef, G Yahya, MS Popoviciu, S Cavalu… - International Journal of …, 2023 - mdpi.com
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …

SGLT2 inhibitors associated pancreatitis: signal identification through disproportionality analysis of spontaneous reports and review of case reports

H Palapra, SK Viswam, V Kalaiselvan… - International Journal of …, 2022 - Springer
Background In recent times, pancreatitis has been one of the most frequently reported
adverse events for sodium-glucose cotransporter-2 (SGLT2) inhibitors. Aim To evaluate the …

Risk of pancreatitis and pancreatic carcinoma for anti-diabetic medications: findings from real-world safety data analysis and systematic review and meta-analysis of …

A Muhammed, C Thomas, V Kalaiselvan… - Expert Opinion on …, 2024 - Taylor & Francis
Background The existing evidence from pre-and post-marketing studies is conflicting on the
risk of pancreatic events for anti-diabetic medications. Research design and methods A …

Adverse events and drug–drug interactions of sodium glucose co-transporter 2 inhibitors in patients treated for heart failure

C Stöllberger, J Finsterer… - Expert Review of …, 2023 - Taylor & Francis
Introduction Sodium glucose co-transporter 2-inhibitors (SGLT2-I), antihyperglycemic
agents, are increasingly prescribed in chronic heart failure (CHF). Their risk for drug–drug …

Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review

SAG Lava, C Laurence, A Di Deo, N Sekarski, M Burch… - Pediatric Drugs, 2024 - Springer
Introduction In adults, sodium-glucose cotransporter type 2 inhibitors have revolutionised the
treatment of type 2 diabetes mellitus, heart failure, and chronic kidney disease. Objective We …

Risk of acute pancreatitis among new users of empagliflozin compared to sulfonylureas in patients with type 2 diabetes: A post‐authorization safety study

S Fazeli Farsani, K Iglay, L Zhang… - … and Drug Safety, 2024 - Wiley Online Library
Purpose This study was undertaken to evaluate the potential risk of acute pancreatitis with
empagliflozin in patients with type 2 diabetes (T2D) newly initiating empagliflozin. Methods …

A Description of Acute Renal Failure and Nephrolithiasis Associated With Sodium–Glucose Co-Transporter 2 Inhibitor Use: A VigiBase Study

I Frent, D Leucuta, C Bucsa, A Farcas… - Frontiers in …, 2022 - frontiersin.org
Background: The Food and Drug Administration issued a warning on the risk of acute kidney
injury and a signal of nephrolithiasis for patients using sodium–glucose co-transporter 2 …

Identification of novel signals associated with US-FDA approved drugs (2013) using disproportionality analysis

S Raghuvanshi, MA Rahman, MK Posa… - Current Drug …, 2024 - ingentaconnect.com
Background: Drugs are related with various adverse drug reactions (ADRs), however, many
unexpected ADRs of drugs are reported through post-marketing surveillance. Aim: The …

Rituximab and Pyoderma Gangrenosum: An Investigation of Disproportionality Using a Systems Biology-Informed Approach in the FAERS Database

JB Hillen, T Stanford, M Ward, EE Roughead… - Drugs-Real World …, 2022 - Springer
Background Studies have found an increased risk of pyoderma gangrenosum associated
with rituximab. The structural properties and pharmacological action of rituximab may affect …

[HTML][HTML] Dapagliflozin-Induced Acute Pancreatitis: A Case Presentation and Review of the Literature

P Issa, D Agapakis, K Machaira, K Ioannis, G Kotronis - Cureus, 2024 - ncbi.nlm.nih.gov
Acute pancreatitis has been considered a rare potential adverse effect of sodium-glucose co-
transporter-2 inhibitors (SGLT-2is), a new class of medications recently approved for use as …