Metabolite-based biosensors for natural product discovery and overproduction

S Shi, Y Xie, G Wang, Y Luo - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Biosensors responding to metabolites were constructed at genetic level.•The
optimization of biosensors for different targets was summarized.•Biosensors could be …

Modern trends in natural antibiotic discovery

AA Baranova, VA Alferova, VA Korshun, AP Tyurin - Life, 2023 - mdpi.com
Natural scaffolds remain an important basis for drug development. Therefore, approaches to
natural bioactive compound discovery attract significant attention. In this account, we …

Synergetic antimicrobial activity and mechanism of clotrimazole-linked CO-releasing molecules

SS Mendes, J Marques, E Mesterházy… - ACS bio & med …, 2022 - ACS Publications
Several metal-based carbon monoxide-releasing molecules (CORMs) are active CO donors
with established antibacterial activity. Among them, CORM conjugates with azole antibiotics …

The microbiome-derived antibacterial lugdunin acts as a cation ionophore in synergy with host peptides

A Berscheid, J Straetener, NA Schilling, D Ruppelt… - Mbio, 2024 - journals.asm.org
Lugdunin is a microbiome-derived antibacterial agent with good activity against Gram-
positive pathogens in vitro and in animal models of nose colonization and skin infection. We …

Investigation into the mechanism of action of the antimicrobial peptide epilancin 15X

C Wu, BA Lower, R Moreira, D Dorantes, T Le… - Frontiers in …, 2023 - frontiersin.org
Addressing the current antibiotic-resistance challenge would be aided by the identification of
compounds with novel mechanisms of action. Epilancin 15X, a lantibiotic produced by …

Sensing of antibiotic–bacteria interactions

AA Baranova, AP Tyurin, VA Korshun, VA Alferova - Antibiotics, 2023 - mdpi.com
Sensing of antibiotic–bacteria interactions is an important area of research that has gained
significant attention in recent years. Antibiotic resistance is a major public health concern …

[HTML][HTML] We need to plan streamlined environmental impact assessment for the future X-Press Pearl disasters

X Zhang, Y Zhu, B Li, B Tefsen, Z Wang, M Wells - Marine Pollution Bulletin, 2023 - Elsevier
Abstract The X-Press Pearl disaster illustrates the urgent needs for streamlined
environmental impact assessment to inform decision making. The environmental …

Ψ-Footprinting approach for the identification of protein synthesis inhibitor producers

F Handel, A Kulik, KW Wex, A Berscheid… - NAR Genomics and …, 2022 - academic.oup.com
Today, one of the biggest challenges in antibiotic research is a targeted prioritization of
natural compound producer strains and an efficient dereplication process to avoid undesired …

Development of an agar-plug cultivation system for bioactivity assays of actinomycete strain collections

N Ortlieb, E Klenk, A Kulik, THJ Niedermeyer - PLoS One, 2021 - journals.plos.org
Natural products are an important source of lead compounds for the development of drug
substances. Actinomycetes have been valuable especially for the discovery of antibiotics …

Ticagrelor alters the membrane of Staphylococcus aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance

K Leeten, N Jacques, LA Esquembre, DC Schneider… - Mbio, 2024 - journals.asm.org
Infections with multidrug-resistant bacteria pose a major healthcare problem which urges the
need for novel treatment options. Besides its potent antiplatelet properties, ticagrelor has …