Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus,
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …

Intracellular bacteria in cancer—Prospects and debates

L Schorr, M Mathies, E Elinav, J Puschhof - npj Biofilms and …, 2023 - nature.com
Recent evidence suggests that some human cancers may harbor low-biomass microbial
ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in …

Microbiota and oral cancer as a complex and dynamic microenvironment: a narrative review from etiology to prognosis

P Pignatelli, FM Romei, D Bondi, M Giuliani… - International journal of …, 2022 - mdpi.com
A complex balanced equilibrium of the bacterial ecosystems exists in the oral cavity that can
be altered by tobacco smoking, psychological stressors, bad dietary habit, and chronic …

Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer

GN Belibasakis, CJ Seneviratne… - Periodontology …, 2024 - Wiley Online Library
It has long been considered that the oral microbiome is tightly connected to oral health and
that dysbiotic changes can be detrimental to the occurrence and progression of dysplastic …

[HTML][HTML] Pathogenesis of periodontitis–A potential role for epithelial-mesenchymal transition

SS Saliem, SY Bede, PR Cooper… - … Dental Science Review, 2022 - Elsevier
Epithelial mesenchymal transition (EMT) is a process comprising cellular and molecular
events which result in cells shifting from an epithelial to a mesenchymal phenotype …

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Z Wang, W Sun, R Hua, Y Wang, Y Li… - International Journal of …, 2024 - nature.com
Despite decades of research, cancer continues to be a major global health concern. The
human mouth appears to be a multiplicity of local environments communicating with other …

Social networking at the microbiome-host interface

RJ Lamont, G Hajishengallis, H Koo - Infection and Immunity, 2023 - Am Soc Microbiol
Microbial species colonizing host ecosystems in health or disease rarely do so alone.
Organisms conglomerate into dynamic heterotypic communities or biofilms in which …

Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer

S Kwak, C Wang, M Usyk, F Wu, ND Freedman… - JAMA …, 2024 - jamanetwork.com
Importance The oral microbiota may be involved in development of head and neck
squamous cell cancer (HNSCC), yet current evidence is largely limited to bacterial 16S …

Emergence of Antibiotic-Resistant Porphyromonas gingivalis in United States Periodontitis Patients

TE Rams, JD Sautter, AJ van Winkelhoff - Antibiotics, 2023 - mdpi.com
Antibiotic resistance patterns of the major human periodontal pathogen Porphyromonas
gingivalis were assessed over a 20-year period in the United States. Subgingival P …

The role of oral microbiota in cancer

Z Lan, WJ Liu, H Cui, KL Zou, H Chen… - Frontiers in …, 2023 - frontiersin.org
Cancer remains a significant global challenge, with an estimated 47% increase in cancer
patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor …