Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Enzymes turnover substrates into products with amazing efficiency and selectivity and as
such have great potential for use in biotechnology and pharmaceutical applications …

The biodegradability of many fluorinated compounds is limited due to the robustness of the
C F bond. Recently, experimental studies suggested the potential involvement of …

Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …

Background: Cytochromes P450 (CYPs) are heme-containing oxidoreductase enzymes with
mono-oxygenase activity. Human CYPs catalyze the oxidation of a great variety of …

Sunitinib (SUN) is an orally administered tyrosine kinase inhibitor and is mainly metabolized
via N-deethylation to form the primary active metabolite N-desethyl-sunitinib (M1) and via …

To investigate the metabolic transformation of cyclopiazonic acid (CPA) in the liver of
different species and to supplement accurate risk assessment information, the metabolism of …

At present, receptor tyrosine kinase signaling-related pathways have been successfully
mediated to inhibit tumor proliferation and promote anti-angiogenesis effects for cancer …

Abstract 4′ Cl‐cumyl‐PINACA (SGT‐157), 4′ F‐cumyl‐5F‐PINACA (4F‐cumyl‐5F‐
PINACA, SGT‐65) and 4′ F‐cumyl‐5F‐PICA (4F‐cumyl‐5F‐PICA, SGT‐64) are a series of …

Targeted covalent inhibitors, primarily targeting cysteine residues, have attracted great
attention as potential drug candidates due to good potency and prolonged duration of …