Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

The escalating misuse and excessive utilization of antibiotics have led to the widespread
dissemination of drug-resistant bacteria, posing a significant global healthcare crisis. Of …

Klebsiella pneumoniae is one of the most common pathogens responsible for infections,
including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence …

Spread of the carbapenemase-encoding and mobilized colistin resistance (mcr) genes
among Enterobacteriales poses a great threat to global public health, especially when the …

Colistin and tigecycline are the last options against carbapenem-resistant hypervirulent
Klebsiella pneumoniae (CR-hvKP). Intersecting resistance determinants have been …

Antibiotic resistance is fast spreading globally, leading to treatment failures and adverse
clinical outcomes. This review focuses on the resistance mechanisms of the top five …

The emergence and transmission of carbapenem-resistant Klebsiella pneumoniae (CRKP)
have been recognized as a major public health concern. Here, we investigated the …

In the following systematic review and meta‐analyses, we report several conclusions about
resistance to carbapenem and polymyxin last‐resort antibiotics for treating multidrug …

Worldwide spread of Enterobacteriaceae resistant to colistin, a polypeptide antibacterial
drug for last-resort treatment of carbapenemase-producing Enterobacteriaceae (CPE) …

Colistin (polymyxin E) and polymyxin B have been used as last-resort agents for treating
infections caused by multidrug-resistant Gram-negative bacteria. However, their efficacy has …