Frequency and implications of HIV superinfection
HIV superinfection occurs when an individual with HIV is infected with a new distinct HIV
viral strain. Superinfection has been reported throughout the world, and studies have …
viral strain. Superinfection has been reported throughout the world, and studies have …
Monkeying around with HIV vaccines: using rhesus macaques to define'gatekeepers' for clinical trials
DJ Shedlock, G Silvestri, DB Weiner - Nature Reviews Immunology, 2009 - nature.com
Rhesus macaques are an important animal model for the study of human disease and the
development of vaccines against HIV and AIDS. HIV vaccines have been benchmarked in …
development of vaccines against HIV and AIDS. HIV vaccines have been benchmarked in …
Prospective study of acute HIV-1 infection in adults in East Africa and Thailand
ML Robb, LA Eller, H Kibuuka, K Rono… - … England Journal of …, 2016 - Mass Medical Soc
Background Acute human immunodeficiency virus type 1 (HIV-1) infection is a major
contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be …
contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be …
Sources of HIV incidence among stable couples in sub‐Saharan Africa
H Chemaitelly, SF Awad, JD Shelton… - African Journal of …, 2014 - journals.lww.com
Methods We constructed a cohort‐type mathematical model that estimates the contribution
of HIV incidence stratified by couple status and source of infection to total HIV incidence in …
of HIV incidence stratified by couple status and source of infection to total HIV incidence in …
Only a fraction of new HIV infections occur within identifiable stable discordant couples in sub-Saharan Africa
Objective: To estimate the contribution of HIV-1 sero-conversions among stable HIV sero-
discordant couples (SDCs) to total HIV population-level incidence in sub-Saharan Africa …
discordant couples (SDCs) to total HIV population-level incidence in sub-Saharan Africa …
CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
F Boufassa, A Saez-Cirion, J Lechenadec, D Zucman… - PLoS …, 2011 - journals.plos.org
Background There are few large published studies of HIV controllers with long-term
undetectable viral load (VL). We describe the characteristics and outcomes of 81 French HIV …
undetectable viral load (VL). We describe the characteristics and outcomes of 81 French HIV …
Programmatic implications of acute and early HIV infection
AB Suthar, RM Granich, M Kato… - The Journal of …, 2015 - academic.oup.com
Human immunodeficiency virus (HIV) infection includes acute, early, chronic, and late
stages. Acute HIV infection lasts approximately 3 weeks and early HIV infection, which …
stages. Acute HIV infection lasts approximately 3 weeks and early HIV infection, which …
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C
JK Wright, V Novitsky, MA Brockman… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT HLA class I-mediated selection of immune escape mutations in functionally
important Gag epitopes may partly explain slower disease progression in HIV-1-infected …
important Gag epitopes may partly explain slower disease progression in HIV-1-infected …
Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection
Objective: The present study addressed two questions: what fraction of individuals maintain
a sustained high HIV-1 RNA load after the acute HIV-1C infection peak and how long is a …
a sustained high HIV-1 RNA load after the acute HIV-1C infection peak and how long is a …
HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the “test-and-treat” approach to reduce HIV transmission
The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …