The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

Brain dopamine (DA) has long been implicated in cognitive control processes, including
working memory. However, the precise role of DA in cognition is not well-understood, partly …

Research into the heterogeneous nature of cognitive impairment documented in patients
with Parkinson's disease (PD) has focused on disentangling deficits that vary between …

Several studies, including work from the Parkinson's disease (PD) non-motor group and
others, have established that the non-motor symptoms of PD are common, occur across all …

A dopaminergic deficiency in patients with Parkinson's disease (PD) causes abnormalities of
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …

We tested whether behavioural manifestations of mental fatigue may be linked to
compromised executive control, which refers to the ability to regulate perceptual and motor …

It is well recognised that patients with Parkinson's disease exhibit cognitive deficits, even in
the earliest disease stages. Whereas, l-DOPA therapy in early Parkinson's disease is …

Goal-directed action in changing environments requires a dynamic balance between
complementary control modes, which serve antagonistic adaptive functions (eg, to shield …

OBJECTIVES: Cognitive impairment is a common feature in Parkinson's disease (PD) and is
an important predictor of quality of life. Past studies showed that some aspects of cognition …

We have used multiple sources to identify a population‐representative cohort of newly
diagnosed patients with parkinsonism and Parkinson's disease in the UK over a 2‐year …