This review provides a concise summary of the changing phenotypes of macrophages and
fibroblastic cells during the local inflammatory response, the onset of tissue repair, and the …

The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt
reporter transgenes, β-catenin's dual roles in adhesion and signaling, and hair follicle …

Mammalian skin and its appendages constitute the integumentary system forming a barrier
between the organism and its environment. During development, skin epidermal cells divide …

Previous attempts to gain insight into the pathogenesis of psoriasis and eczema by
comparing their molecular signatures were hampered by the high interindividual variability …

The ability of vertebrates to regenerate amputated appendages is increasingly well-
understood at the cellular level. Cells mediating an innate immune response and …

Wnts are transported to the cell surface by the integral membrane protein WLS (also known
as Wntless, Evi, and GPR177). Previous studies of WLS trafficking have emphasized WLS …

How stem cells maintain their identity and potency as tissues change during growth is not
well understood. In mammalian hair, it is unclear how hair follicle stem cells can enter an …

Cell-cell communication via Wnt ligands is necessary in regulating embryonic development
and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the …

Background Structural birth defects occur in approximately 3% of live births; most such
defects lack defined genetic or environmental causes. Despite advances in surgical …