This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in
neuroplasticity and nervous system disorders, and therapeutic implications of integrins as …

In the central nervous system, various extracellular matrix components have been identified
which are strongly expressed during development and in most areas of the brain down …

Demyelination is the hallmark of numerous neurodegenerative conditions, including multiple
sclerosis. Oligodendrocyte progenitors (OPCs), which normally mature into myelin-forming …

Although the extracellular matrix plays an important role in regulating use-dependent
synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we …

During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of
polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap …

Epilepsies are multifaceted neurological disorders characterized by abnormal brain activity,
eg caused by imbalanced synaptic excitation and inhibition. The neural extracellular matrix …

Extracellular matrix (ECM) in the brain is composed of molecules synthesized and secreted
by neurons and glial cells in a cell-type-specific and activity-dependent manner. During …

Perineuronal matrix is an extracellular protein scaffold to shape neuronal responsiveness
and survival. Whilst perineuronal nets engulf the somatodendritic axis of neurons, axonal …

As a major producer of the inflammatory cytokine interleukin-1 (IL-1), peripheral
macrophages can augment IL-1 expression via type 1 IL-1 receptor (IL-1R1) mediated …