Ribosomes that stall during translation need to be rescued to ensure that the protein
synthesis capacity of the cell is maintained. Stalling arises when ribosomes become trapped …

During protein synthesis, translating ribosomes encounter many challenges imposed by
various types of defective mRNAs that can lead to reduced cellular fitness and, in some …

Ribosome stalling during translation is detrimental to cellular fitness, but how this is sensed
and elicits recycling of ribosomal subunits and quality control of associated mRNA and …

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis
must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue …

Ribonucleases (RNases) play an essential role in essentially every aspect of RNA
metabolism, but they also can be destructive enzymes that need to be regulated to avoid …

5′ exoribonucleases are key enzymes in the degradation of superfluous or aberrant RNAs
and in the maturation of precursor RNAs into their functional forms. The major bacterial 3 …

Gene expression not only depends on the rate of transcription but is also largely controlled
at the post-transcriptional level. Translation rate and mRNA decay greatly influence the final …

Genes for the RNA tmRNA and protein SmpB, partners in the trans-translation process that
rescues stalled ribosomes, have previously been found in all bacteria and some organelles …

RNA metabolism needs to be tightly regulated in response to changes in cellular physiology.
Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism …

Small protein B (SmpB) cooperates with transfer-messenger RNA (tmRNA) for trans-
translation to ensure the quality control of protein synthesis in prokaryotes. Furthermore, they …