[HTML][HTML] Translation and replication dynamics of single RNA viruses
RNA viruses are among the most prevalent pathogens and are a major burden on society.
Although RNA viruses have been studied extensively, little is known about the processes …
Although RNA viruses have been studied extensively, little is known about the processes …
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3
K Wang, C Zou, X Wang, C Huang, T Feng… - PLoS …, 2018 - journals.plos.org
In order to eliminate viral infections, hundreds of interferon-stimulated genes (ISGs) are
induced via type I interferons (IFNs). However, the functions and mechanisms of most ISGs …
induced via type I interferons (IFNs). However, the functions and mechanisms of most ISGs …
IFN-stimulated genes in zebrafish and humans define an ancient arsenal of antiviral immunity
JP Levraud, L Jouneau, V Briolat, V Laghi… - The Journal of …, 2019 - journals.aai.org
The evolution of the IFN system, the major innate antiviral mechanism of vertebrates,
remains poorly understood. According to the detection of type I IFN genes in cartilaginous …
remains poorly understood. According to the detection of type I IFN genes in cartilaginous …
Viral priming of cell intrinsic innate antiviral signaling by the unfolded protein response
T Carletti, MK Zakaria, V Faoro, L Reale… - Nature …, 2019 - nature.com
The innate response to a pathogen is critical in determining the outcome of the infection.
However, the interplay of different cellular responses that are activated following viral …
However, the interplay of different cellular responses that are activated following viral …
A CRISPR activation screen identifies genes that protect against Zika virus infection
Zika virus (ZIKV) is an arthropod-borne emerging pathogen causing febrile illness. ZIKV is
associated Guillain-Barré syndrome and other neurological complications. Infection during …
associated Guillain-Barré syndrome and other neurological complications. Infection during …
Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses
DF van den Berg, AR Costa, JQ Esser, I Stanciu… - Cell Host & Microbe, 2024 - cell.com
Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
Conservation of antiviral systems across domains of life reveals novel immune mechanisms in humans
Viral infection is a common threat to prokaryotic and eukaryotic life, which has resulted in the
evolution of a myriad of antiviral systems. Some of these eukaryotic systems are thought to …
evolution of a myriad of antiviral systems. Some of these eukaryotic systems are thought to …
Functional and molecular dissection of HCMV long non-coding RNAs
S Lee, H Kim, A Hong, J Song, S Lee, M Kim… - Scientific Reports, 2022 - nature.com
Small, compact genomes confer a selective advantage to viruses, yet human
cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1. 2, RNA2 …
cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1. 2, RNA2 …
[HTML][HTML] Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes
An urgent question of coronavirus disease 2019 (COVID-19) is population variation in
susceptibility to SARS-CoV-2 infection and symptom severity. We explore the expression …
susceptibility to SARS-CoV-2 infection and symptom severity. We explore the expression …
Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions
Despite the association of prevalent health conditions with coronavirus disease 2019
(COVID-19) severity, the disease-modifying biomolecules and their pathogenetic …
(COVID-19) severity, the disease-modifying biomolecules and their pathogenetic …