The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …

Background Breathing exercises have been widely used worldwide as a non‐
pharmacological therapy to treat people with asthma. Breathing exercises aim to control the …

Background Tezepelumab is a human monoclonal antibody that blocks the activity of thymic
stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies …

Background The effectiveness of bronchial thermoplasty (BT) has been reported in patients
with severe asthma, yet its effect on different bronchial structures remains unknown …

Abstract The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma
guidelines for the diagnosis and management of asthma for adults and children, which is …

Asthma is a chronic inflammatory airway disease involving complex interplay between
resident and infiltrative cells, which in turn are regulated by a wide range of host mediators …

Background Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous
diseases. Objective We sought to determine, in terms of their sputum cellular and mediator …

Asthma is a common chronic inflammatory condition of the airways that affects about 350
million people globally. In 5%–10% of individuals, it is severe, with considerable morbidity …

Background Severe refractory asthma is a heterogeneous disease. We sought to determine
statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to …

Background In some people with asthma, expiratory airflow limitation, premature closure of
small airways, activity of inspiratory muscles at the end of expiration and reduced pulmonary …