Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

The rare coagulation disorders are heritable abnormalities of haemostasis that may present
significant difficulties in diagnosis and management. This review summarizes the current …

This is the second edition of our little red book Lectins published in 1989. In the intervening
years well over 10,000 articles have appeared with lectins as the main subject, and more …

▪ Abstract Green fluorescent protein chimerae acting as reporters for protein localization and
trafficking within the secretory membrane system of living cells have been used in a wide …

Estimates based on proteomic analyses indicate that a third of translated proteins in
eukaryotic genomes enter the secretory pathway. After folding and assembly of nascent …

Factor VIII (FVIII) functions as a cofactor within the intrinsic pathway of blood coagulation.
Quantitative or qualitative deficiencies of FVIII result in the inherited bleeding disorder …

Mutations in LMAN1 (also called ERGIC-53) result in combined deficiency of factor V and
factor VIII (F5F8D), an autosomal recessive bleeding disorder characterized by coordinate …

Lectins are multivalent proteins with the ability to recognize and bind diverse carbohydrate
structures. The glyco-binding and diverse molecular structures observed in these protein …

The secretory pathway is composed of membrane compartments specialized in protein
folding, modification, transport, and sorting. Numerous transient protein-protein interactions …

Textbook of hemophilia Textbook of Hemophilia Page 2 Textbook of Hemophilia Edited by
Christine A. Lee MA, MD, DSc (Med), FRCP, FRCPath Professor of Haemophilia Director and …