Arrhythmogenic cardiomyopathy has been clinically defined since the 1980s and causes
right or biventricular cardiomyopathy associated with ventricular arrhythmia. Although it is a …

The cardiac sodium channel NaV1. 5 is an essential modulator of cardiac excitability, with
decreased NaV1. 5 levels at the plasma membrane and consequent reduction in sodium …

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality,
cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS …

Background: Childhood-onset cardiomyopathy is a heterogeneous group of conditions the
cause of which is largely unknown. The influence of consanguinity on the genetics of …

Maintenance of immunological homeostasis between tolerance and autoimmunity is
essential for the prevention of human diseases ranging from autoimmune disease to cancer …

Background Bovine congestive heart failure (BCHF) has become increasingly prevalent
among feedlot cattle in the Western Great Plains of North America with up to 7% mortality in …

The complex interaction between cancer cells and the immune microenvironment is a
central regulator of tumor growth and the treatment response. Chemotherapy-induced …

The transcription factor p63 is expressed in many different isoforms as a result of differential
promoter use and splicing. Some of these isoforms have very specific physiological …

Discrete categorization of Mendelian disease genes into dominant and recessive models
often oversimplifies their underlying genetic architecture. Cardiomyopathies (CMs) are …

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that
regulates myriad genes instrumental in diverse cellular outcomes including growth arrest …