Recent advancements in mass spectrometry (MS) have revolutionized quantitative
proteomics, with multiplex isotope labeling emerging as a key strategy for enhancing …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

Limited proteolysis coupled to mass spectrometry (LiP-MS) has emerged as a powerful
proteomic tool for studying protein conformations. Since its introduction in 2014, LiP-MS has …

Mass spectrometry-based methods can provide a global expression profile and structural
readout of proteins in complex systems. Preserving the in vivo conformation of proteins in …

Benzene is known to be a common toxic industrial chemical, and prolonged benzene
exposure may cause nervous system damage. At present, there were few studies on …

Abstract Changes in protein homeostasis are broadly implicated in many disease states,
including amyloidoses, neurodegenerative diseases, cancer, and normal aging. Although …

“IgG’s: contending with aggregating circumstances” - PMC Skip to main content Here's how you
know Official websites use .gov A .gov website belongs to an official government organization …

Central nervous system (CNS) drug development is plagued by high clinical failure rate.
Phenotypic assays promote clinical translation of drugs by reducing complex brain diseases …