The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …

The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, eg,
through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common …

Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B
cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …

Interleukin-21 is a cytokine with broad pleiotropic actions that affect the differentiation and
function of lymphoid and myeloid cells. Since its discovery in 2000, a tremendous amount …

Although a fraction of human blood memory CD4+ T cells expresses chemokine (CXC motif)
receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established …

T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …