Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Obesity is a low chronic inflammatory state because several inflammatory factors are
increased in obese subjects, this having important implications for the onset of obesity …

Invasive graft biopsies assess the efficacy of immunosuppression through lagging indicators
of transplant rejection. We report on a microporous scaffold implant as a minimally invasive …

The life-saving benefits of organ transplantation can be thwarted by allograft dysfunction due
to both infectious and sterile inflammation post-surgery. Sterile inflammation can occur after …

Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are
generated in response to cell stress and activate innate immunity to provide a pivotal …

Background Costimulatory blockade provides new therapeutic opportunities for ensuring the
long-term survival of kidney grafts. The adoption of the novel immunosuppressant …

Essentials• Inflammation plays a key role in the development of colorectal cancer.•
Understanding mechanisms of cancer initiation might reveal new anticancer preventive …

Damage-associated molecular patterns (DAMPs) play a critical role in dendritic cells (DCs)
ability to trigger a specific and efficient adaptive immune response for different physiological …

Phagocytic sensing and engulfment of dying cells and extracellular bodies initiate an
intracellular signaling cascade within the phagocyte that can polarize cellular function and …

Objective: This study aims to explore the clinical significance of haptoglobin (HP) and
protein disulfide-isomerase A3 (PDIA3) in human serum in the screening, diagnosis and …