New insight into phytochromes: connecting structure to function

J Hughes, A Winkler - Annual review of plant biology, 2024 - annualreviews.org
Red and far-red light–sensing phytochromes are widespread in nature, occurring in plants,
algae, fungi, and prokaryotes. Despite at least a billion years of evolution, their photosensory …

Thermal reversion of plant phytochromes

C Klose, F Nagy, E Schäfer - Molecular Plant, 2020 - cell.com
Phytochromes are red/far-red reversible photoreceptors essential for plant growth and
development. Phytochrome signaling is mediated by the physiologically active far-red …

A red light–responsive photoswitch for deep tissue optogenetics

Y Kuwasaki, K Suzuki, G Yu, S Yamamoto… - Nature …, 2022 - nature.com
Red light penetrates deep into mammalian tissues and has low phototoxicity, but few
optogenetic tools that use red light have been developed. Here we present MagRed, a red …

Crystal structure of Deinococcus phytochrome in the photoactivated state reveals a cascade of structural rearrangements during photoconversion

ES Burgie, J Zhang, RD Vierstra - Structure, 2016 - cell.com
Phytochromes are photochromic photoreceptors responsible for a myriad of red/far-red light-
dependent processes in plants and microorganisms. Interconversion is initially driven by …

Structural photoactivation of a full-length bacterial phytochrome

A Björling, O Berntsson, H Lehtivuori, H Takala… - Science …, 2016 - science.org
Phytochromes are light sensor proteins found in plants, bacteria, and fungi. They function by
converting a photon absorption event into a conformational signal that propagates from the …

Long-range allosteric signaling in red light–regulated diguanylyl cyclases

G Gourinchas, S Etzl, C Göbl, U Vide, T Madl… - Science …, 2017 - science.org
Nature has evolved an astonishingly modular architecture of covalently linked protein
domains with diverse functionalities to enable complex cellular networks that are critical for …

Tips and turns of bacteriophytochrome photoactivation

H Takala, P Edlund, JA Ihalainen… - Photochemical & …, 2020 - pubs.rsc.org
Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction
and movement in plants, fungi and bacteria. Phytochromes switch between two …

On the (un) coupling of the chromophore, tongue interactions, and overall conformation in a bacterial phytochrome

H Takala, HK Lehtivuori, O Berntsson, A Hughes… - Journal of Biological …, 2018 - ASBMB
Phytochromes are photoreceptors in plants, fungi, and various microorganisms and cycle
between metastable red light–absorbing (Pr) and far-red light–absorbing (Pfr) states. Their …

The interconnecting hairpin extension" arm": An essential allosteric element of phytochrome activity

M Kurttila, J Rumfeldt, H Takala, JA Ihalainen - Structure, 2023 - cell.com
In red-light sensing phytochromes, isomerization of the bilin chromophore triggers structural
and dynamic changes across multiple domains, ultimately leading to control of the output …

Light-induced changes in the dimerization interface of bacteriophytochromes

H Takala, A Björling, M Linna, S Westenhoff… - Journal of Biological …, 2015 - ASBMB
Phytochromes are dimeric photoreceptor proteins that sense red light levels in plants, fungi,
and bacteria. The proteins are structurally divided into a light-sensing photosensory module …