Sesamin and sesamolin rescues Caenorhabditis elegans from Pseudomonas aeruginosa infection through the attenuation of quorum sensing regulated virulence …
Pseudomonas aeruginosa is an opportunistic pathogen emerging as a public health threat
owing to their multidrug resistance profiles. The quorum sensing systems of P. aeruginosa …
owing to their multidrug resistance profiles. The quorum sensing systems of P. aeruginosa …
Potent bioactive compounds from seaweed waste to combat cancer through bioinformatics investigation
The seaweed industries generate considerable amounts of waste that must be appropriately
managed. This biomass from marine waste is a rich source of high-value bioactive …
managed. This biomass from marine waste is a rich source of high-value bioactive …
Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein
KK Bharadwaj, B Rabha, I Ahmad… - Journal of …, 2024 - Taylor & Francis
Overexpression of HDAC 2 promotes cell proliferation in ovarian cancer. HDAC 2 is involved
in chromatin remodeling, transcriptional repression, and the formation of condensed …
in chromatin remodeling, transcriptional repression, and the formation of condensed …
Mutations of SARS-CoV-2 RBD may alter its molecular structure to improve its infection efficiency
The receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) mediates the viral–host interaction and is a target for most neutralizing …
(SARS-CoV-2) mediates the viral–host interaction and is a target for most neutralizing …
Target specific inhibition of protein tyrosine kinase in conjunction with cancer and SARS-COV-2 by olive nutraceuticals
The fact that viruses cause human cancer dates back to the early 1980s. By reprogramming
cellular signaling pathways, viruses encoded protein that can regulate altered control of cell …
cellular signaling pathways, viruses encoded protein that can regulate altered control of cell …
Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus
The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the
Togaviridae family's Alphavirus genus. An epidemic was observed among French troops …
Togaviridae family's Alphavirus genus. An epidemic was observed among French troops …
Macrolactin A as a Novel Inhibitory Agent for SARS-CoV-2 Mpro: Bioinformatics Approach
COVID-19 is a disease that puts most of the world on lockdown and the search for
therapeutic drugs is still ongoing. Therefore, this study used in silico screening to identify …
therapeutic drugs is still ongoing. Therefore, this study used in silico screening to identify …
Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease
Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain that manifests
as dementia, disorientation, difficulty in speech, and progressive cognitive and behavioral …
as dementia, disorientation, difficulty in speech, and progressive cognitive and behavioral …
Screening of phytocompounds for identification of prospective histone deacetylase 1 (HDAC1) inhibitor: an in silico molecular docking, molecular dynamics simulation …
The upregulation of HDAC1 facilitate the induction of epigenetic repression of genes
responsible for suppressing tumourigenesis, thereby triggering the development of cancer …
responsible for suppressing tumourigenesis, thereby triggering the development of cancer …
Nonlinear molecular dynamics of quercetin in Gynocardia odorata and Diospyros malabarica fruits: Its mechanistic role in hepatoprotection
A Ghosh, P Sarmah, H Patel, N Mukerjee, R Mishra… - PLoS …, 2022 - journals.plos.org
Liver performs number of critical physiological functions in human system. Intoxication of
liver leads to accumulation of free radicals that eventually cause damage, fibrosis, cirrhosis …
liver leads to accumulation of free radicals that eventually cause damage, fibrosis, cirrhosis …