Metabolites as signalling molecules

SA Baker, J Rutter - Nature reviews molecular cell Biology, 2023 - nature.com
Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

[HTML][HTML] Exploring the journey of emodin as a potential neuroprotective agent: novel therapeutic insights with molecular mechanism of action

S Mitra, J Anjum, M Muni, R Das, A Rauf, F Islam… - Biomedicine & …, 2022 - Elsevier
Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants,
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

R Dang, M Wang, X Li, H Wang, L Liu, Q Wu… - Journal of …, 2022 - Springer
Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

[HTML][HTML] SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging

HC Chang, L Guarente - Cell, 2013 - cell.com
SIRT1 is a NAD+-dependent protein deacetylase that governs many physiological
pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the …

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism

R Nogueiras, KM Habegger… - Physiological …, 2012 - journals.physiology.org
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

SIRT1 in neurodevelopment and brain senescence

AZ Herskovits, L Guarente - Neuron, 2014 - cell.com
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Gut microbiota in anxiety and depression: unveiling the relationships and management options

A Kumar, J Pramanik, N Goyal, D Chauhan… - Pharmaceuticals, 2023 - mdpi.com
The gut microbiota is critical for maintaining human health and the immunological system.
Several neuroscientific studies have shown the significance of microbiota in developing …

How might circadian rhythms control mood? Let me count the ways...

CA McClung - Biological psychiatry, 2013 - Elsevier
Mood disorders are serious diseases that affect a large portion of the population. There have
been many hypotheses put forth over the years to explain the development of major …

Epigenetics in depression and gut-brain axis: A molecular crosstalk

N Begum, A Mandhare, KP Tryphena… - Frontiers in Aging …, 2022 - frontiersin.org
Gut-brain axis is a dynamic, complex, and bidirectional communication network between the
gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …