MYC-driven medulloblastomas (MB) are highly aggressive pediatric brain tumors with poor
outcomes, and effective therapies remain limited despite intensive multimodal treatments …

Simple Summary Over the last two decades, there has been a major shift in cancer research
models. What was once dominated by genetically engineered mice models and fast-growing …

Simple Summary We review the role of chromatin and epigenetic dysregulation in therapy
resistance in glioblastoma. We discuss how epigenetic and genetic forces may cooperate to …

Here, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor
abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual …

Background Diffuse invasion remains a primary cause of treatment failure in pediatric high-
grade glioma (pHGG). Identifying cellular driver (s) of pHGG invasion is needed for anti …

Radiotherapy has long been a main treatment option for nasopharyngeal carcinoma (NPC).
However, during clinical treatment, NPC is prone to developing radioresistance, resulting in …

Glioblastoma multiforme (GBM) is a highly aggressive malignancy and represents the most
common brain tumor in adults. To better understand its biology for new and effective …

Background Animal models representing different molecular subtypes of glioblastoma
multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus …

Simple Summary This article herein presented explores the role of the epigenetic marker
H3K27me3 in tumors of the Central Nervous System, highlighting its importance for …

Radiation is one of the standard therapies for pediatric high-grade glioma (pHGG), of which
the prognosis remains poor. To gain an in-depth understanding of biological consequences …