Abstract The World Health Organization recently published the 4th edition of the
Classification of Head and Neck Tumors, including several new entities, emerging entities …

Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central
nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is …

Ewing sarcoma shows considerable histologic overlap with other round cell tumors. NKX2-2,
a homeodomain transcription factor involved in neuroendocrine/glial differentiation and a …

Sinonasal tumors with neuroendocrine differentiation form a group of rare heterogeneous
neoplasms of neuroectodermal and epithelial origin, consisting of olfactory neuroblastomas …

Sinonasal neoplasms are uncommon diseases, characterized by heterogeneous biological
behavior, which frequently results in challenges in differential diagnosis and treatment …

Olfactory neuroblastoma (ONB, Esthesioneuroblastoma) is an infrequent neoplasm of the
head and neck area derived from olfactory neuroepithelium. Despite relatively good …

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating
in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and …

Abstract Purpose of Review The purpose of review is to provide a comprehensive review of
the literature focusing on the recent advances in the diagnosis, molecular underpinning, and …

Background Past research established that surgery plus adjuvant radiotherapy (S+ AR)
improves overall survival (OS) in esthesioneuroblastoma (ENB). However, it is unknown if …

Background Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal tract with little
molecular characterization. We performed whole genome sequencing (WGS) on paired …