Fat tissue, aging, and cellular senescence
T Tchkonia, DE Morbeck, T Von Zglinicki… - Aging cell, 2010 - Wiley Online Library
Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …
longevity and age‐related metabolic dysfunction. Fat distribution and function change …
[HTML][HTML] Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism
CT Lutz, LBS Quinn - Aging (Albany NY), 2012 - ncbi.nlm.nih.gov
Human aging is characterized by both physical and physiological frailty. A key feature of
frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and …
frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and …
[HTML][HTML] Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
T Deng, CJ Lyon, LJ Minze, J Lin, J Zou, JZ Liu, Y Ren… - Cell metabolism, 2013 - cell.com
Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity,
but ART activation signals are poorly understood. Here, we describe class II major …
but ART activation signals are poorly understood. Here, we describe class II major …
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
A Bertola, T Ciucci, D Rousseau, V Bourlier… - Diabetes, 2012 - Am Diabetes Assoc
T-cell regulation in adipose tissue provides a link between inflammation and insulin
resistance. Because of alterations in adipose tissue T-cell composition in obesity, we aimed …
resistance. Because of alterations in adipose tissue T-cell composition in obesity, we aimed …
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic …
H Yang, YH Youm, B Vandanmagsar… - The Journal of …, 2010 - journals.aai.org
Emerging evidence suggests that increases in activated T cell populations in adipose tissue
may contribute toward obesity-associated metabolic syndrome. The present study …
may contribute toward obesity-associated metabolic syndrome. The present study …
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …
including obesity and its associated metabolic syndrome. In this paper, we show that the …
Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey
R Kones - Drug design, development and therapy, 2011 - Taylor & Francis
A recent explosion in the amount of cardiovascular risk and incipient, undetected subclinical
cardiovascular pathology has swept across the globe. Nearly 70% of adult Americans are …
cardiovascular pathology has swept across the globe. Nearly 70% of adult Americans are …
A decade of progress in adipose tissue macrophage biology
One decade has passed since seminal publications described macrophage infiltration into
adipose tissue (AT) as a key contributor to inflammation and obesity‐related insulin …
adipose tissue (AT) as a key contributor to inflammation and obesity‐related insulin …
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy
K Eller, A Kirsch, AM Wolf, S Sopper, A Tagwerker… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE To assess the potential role of FoxP3-expressing regulatory T cells (Tregs) in
reversing obesity-linked insulin resistance and diabetic nephropathy in rodent models and …
reversing obesity-linked insulin resistance and diabetic nephropathy in rodent models and …
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now
established that obesity results in a state of chronic low‐grade inflammation thought to …
established that obesity results in a state of chronic low‐grade inflammation thought to …