Transition‐Metal‐Free Synthesis of N‐Heterocyclic Compounds via Multi‐Component Reactions

DJ Boruah, L Borkotoky, UD Newar… - Asian Journal of …, 2023 - Wiley Online Library
Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for
the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing …

Green synthetic strategies toward thiazoles: a sustainable approach

S Pathania, RK Rawal - Chemistry of Heterocyclic Compounds, 2020 - Springer
In current era of environmental crisis, green chemistry has regained a significant role in
overcoming the harmful consequences of conventional chemistry in every aspect. Green …

Metal-Free and Regioselective Synthesis of Substituted and Fused Chromenopyrrole Scaffolds via the Divergent Reactivity of α-Azido Ketones in Water

E Dhanasekar, T Kannan, R Venkatesan… - The Journal of …, 2020 - ACS Publications
A green and simple approach was developed for the regioselective synthesis of structurally
diverse chromenopyrrole frameworks from 3-formylchromones, active methylenes, and α …

Isothiocyanates: happy-go-lucky reagents in organic synthesis

B Das, A Dahiya, BK Patel - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful
and inimitable reagents as the N= C= S group serves both as electrophile and nucleophile …

Transition‐Metal‐Free Reverse Reactivity of (2‐Alkynyl)‐Arylaldimines: Assembly of Functionalized Amino‐Indinones

KM Saini, RK Saunthwal, Sushmita… - … –A European Journal, 2020 - Wiley Online Library
Transition‐metal‐free regioselective synthesis of functionalized amino‐indenones by the
reaction of ortho‐alkynylaldehydes with a broad range of primary amines by intramolecular …

Emerging green synthetic routes for thiazole and its derivatives: Current perspectives

M Patel, T Bambharoliya, D Shah, K Patel… - Archiv der …, 2024 - Wiley Online Library
This review article provides an overview of the green synthesis of thiazole derivatives,
emphasizing sustainable and environmentally friendly methodologies. Thiazole derivatives …

4a Nucleophilic Aromatic Substitution

MR Crampton - Organic Reaction Mechanisms 2020, 2024 - Wiley Online Library
Analogies between the mechanisms of electrophilic substitution and nucleophilic
substitution have been discussed. Theoretical calculations, involving aromaticity …

Nucleophilic Addition and Substitution Reactions In‐Water

PS Devi, PXT Rinu, G Anilkumar - Organic Transformations in …, 2025 - Wiley Online Library
Nucleophilic addition and substitution reactions are foundational pillars of organic synthesis,
indispensable for the construction of diverse molecules ranging from natural products to …

Thiazolo[5,4‐f]quinoxalines, Oxazolo[5,4‐f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6‐Aminoquinoxalines and Properties

F Lassagne, JM Sims, W Erb, O Mongin… - European Journal of …, 2021 - Wiley Online Library
The regioselective iodination of different 2‐mono‐, 3‐mono‐and 2, 3‐disubstituted 6‐
aminoquinoxalines, which takes place at their 5‐position, was rationalized on the basis of …

Base-catalyzed synthesis of quinazolines in aqueous medium

N Jatangi, RK Palakodety - Tetrahedron Letters, 2019 - Elsevier
An alternative green protocol and step economy for the synthesis of quinazoline has been
developed. The reaction of readily available 2-aminobenzonitriles with various …