Alcoholic liver disease
HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
[HTML][HTML] The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
H Zhang, L Fu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
ALDH1A1 activity in tumor-initiating cells remodels myeloid-derived suppressor cells to promote breast cancer progression
Tumor-initiating cells (TIC) are associated with tumor initiation, growth, metastasis, and
recurrence. Aldehyde dehydrogenase 1A1 (ALDH1A1) is a TIC marker in many cancers …
recurrence. Aldehyde dehydrogenase 1A1 (ALDH1A1) is a TIC marker in many cancers …
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles
Background & Aims Excessive alcohol consumption is one of the major causes of
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are …
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are …
Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
[HTML][HTML] A class of environmental and endogenous toxins induces BRCA2 haploinsufficiency and genome instability
SLW Tan, S Chadha, Y Liu, E Gabasova, D Perera… - Cell, 2017 - cell.com
Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer
susceptibility. In cells bearing such heterozygous mutations, we find that a cellular …
susceptibility. In cells bearing such heterozygous mutations, we find that a cellular …
[HTML][HTML] Alcoholic liver disease: A current molecular and clinical perspective
K Ohashi, M Pimienta, E Seki - Liver research, 2018 - Elsevier
Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …
Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay
Aldehyde dehydrogenases (ALDHs) defend intracellular homeostasis by catalyzing the
conversion of toxic aldehydes into non-toxic carboxylic acids, which is of particular …
conversion of toxic aldehydes into non-toxic carboxylic acids, which is of particular …
Alcoholic liver disease: a new insight into the pathogenesis of liver disease
Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases,
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …