N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …

When blood vessels are cut, the forces in the bloodstream increase and change character.
The dark side of these forces causes hemorrhage and death. However, von Willebrand …

Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

In the present study, we re-annotated von Willebrand factor (VWF), assigned its entire
sequence to specific modules, and related these modules to structure using electron …

The attachment of glycans to asparagine residues of proteins is an abundant and highly
conserved essential modification in eukaryotes. The N-glycosylation process includes two …

Abstract von Willebrand factor (vWF) is synthesized in megakaryocytes and endothelial cells
as a very large multimer, but circulates in plasma as a group of multimers ranging from 500 …

For many years, an association between ABO histo‐blood group and risk of thrombosis has
been recognized. Blood group non‐O (A, B, and AB) individuals have consistently been …

Asparagine-linked glycosylation (ALG) is one of the most common protein modification
reactions in eukaryotic cells, as many proteins that are translocated across or integrated into …

Normal hemostasis requires von Willebrand factor (VWF) to support platelet adhesion and
aggregation at sites of vascular injury. VWF is a multimeric glycoprotein built from identical …