Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis
HA Kalpage, V Bazylianska, MA Recanati… - The FASEB …, 2019 - Wiley Online Library
Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …
Multifunctional Cytochrome c: Learning New Tricks from an Old Dog
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
Enzymes that catalyze carbon–silicon bond formation are unknown in nature, despite the
natural abundance of both elements. Such enzymes would expand the catalytic repertoire of …
natural abundance of both elements. Such enzymes would expand the catalytic repertoire of …
Hierarchical micro-and mesoporous ZIF-8 with core–shell superstructures using colloidal metal sulfates as soft templates for enzyme immobilization
Abstract Metal–organic frameworks (MOFs), with large specific surface area and tunable
porosity, have gained lots of attention for immobilizing enzymes. However, the intrinsic open …
porosity, have gained lots of attention for immobilizing enzymes. However, the intrinsic open …
Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis
HA Kalpage, J Wan, PT Morse, MP Zurek… - The international journal …, 2020 - Elsevier
Cytochrome c (Cytc) 1 is a cellular life and death decision molecule that regulates cellular
energy supply and apoptosis through tissue specific post-translational modifications. Cytc is …
energy supply and apoptosis through tissue specific post-translational modifications. Cytc is …
Protein aggregation and neurodegenerative diseases: From theory to therapy
The study of protein misfolding and aggregation saw resurgence in the last decade.
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
[HTML][HTML] Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma
Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …
signaling cascades are stimulated via genetic modifications in upstream signaling …
Metalloprotein entatic control of ligand-metal bonds quantified by ultrafast x-ray spectroscopy
The multifunctional protein cytochrome c (cyt c) plays key roles in electron transport and
apoptosis, switching function by modulating bonding between a heme iron and the sulfur in …
apoptosis, switching function by modulating bonding between a heme iron and the sulfur in …
Current updates on computer aided protein modeling and designing
Determination of the three dimensional (3D) structure of a protein can provide important
details about its biological functions and mechanism of action. However, despite their …
details about its biological functions and mechanism of action. However, despite their …