Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings
B Misiak, M Krefft, T Bielawski, AA Moustafa… - Neuroscience & …, 2017 - Elsevier
There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …
and the risk of developing psychosis. Numerous studies, including many large-scale …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …
Recent genetic findings in schizophrenia and their therapeutic relevance
PJ Harrison - Journal of psychopharmacology, 2015 - journals.sagepub.com
Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
Epigenetic signaling in psychiatric disorders: stress and depression
Psychiatric disorders are complex multifactorial disorders involving chronic alterations in
neural circuit structure and function. While genetic factors play a role in the etiology of …
neural circuit structure and function. While genetic factors play a role in the etiology of …
DNA methylation and schizophrenia: current literature and future perspective
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …
identity, and emotions. It has no central pathophysiological mechanism and precise …
Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …
result from disturbances in early brain development. There is mounting evidence to support …
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
J Viana, E Hannon, E Dempster… - Human molecular …, 2017 - academic.oup.com
Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment
Schizophrenia is a complex psychiatric disorder where genetic, epigenetic, and
environmental factors play a role in disease onset, course of illness, and treatment outcome …
environmental factors play a role in disease onset, course of illness, and treatment outcome …
DNA methylation signature as a biomarker of major neuropsychiatric disorders
Z Shirvani-Farsani, Z Maloum… - Journal of Psychiatric …, 2021 - Elsevier
DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …
as a heritable and reversible change. Previous findings have indicated that DNA methylation …