Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …

The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …

Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …

There is substantial agreement that the unbalance between oxidant and antioxidant species
may affect the onset and/or the course of a number of common diseases including …

Parkinson's disease (PD) biomarkers are needed to enhance therapeutics research and to
understand PD pathogenesis. Methods that simultaneously measure hundreds of small …

Objective: This study investigates salivary gland biopsies in living patients with Parkinson
disease (PD). Methods: Patients with PD for≥ 5 years underwent outpatient transcutaneous …

Exosomes are nanometer-sized vesicles with intercellular communication functions, and
their encapsulated proteins may participate in the pathological process of …

Diagnosis of Parkinson's disease (PD) relies on clinical history and physical examination,
but misdiagnosis is common in early stages. Identification of biomarkers for PD may allow …